Download Citation on ResearchGate | On Dec 31, , Martin H. Floch and others published Dispepsia (dispepsia funcional y dispepsia no ulcerosa) }. Nuestro objetivo fue evaluar los síntomas del síndrome de dispepsia funcional y su mejoría tras la erradicación del Helicobacter pylori. Se evaluaron La dispepsia funcional (DF o dispepsia no ulcerosa) se define como dolor o malestar epigástrico continuo o frecuentemente recurrente para el que no se puede.
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Provavelmente, a droga mais promissora e melhor estudada deste grupo de agentes redutores da sensibilidade visceral seja a fedotozina. New drugs for the treatment of functional dyspepsia.
Arq Gastroenterol ;38 3: Current pharmacological treatment of functional dyspepsia is largely empirical and involves anti-secretory or prokinetic drugs. Aims – To review recent advances in the understanding of the mechanisms involved in symptom production in functional dyspepsia, as well as the development of new drugs that may interfere with these mechanisms, which may lead to more rational and effective treatment of this clinical condition. Method – Systematic review of papers published in English for the last 10 years.
Results – New drugs that increase propulsive gastroduodenal motor activity include new benzamides similar to cisapride, CCK-A blockers, agonists of opiate receptors and motilin agonists similar to erythromycin. A number of agents, including sumatriptan and buspirone, stimulates serotonin receptors in the myoenteric plexuses and have been shown to increase gastric accommodation to a meal. Finally, a number of new drugs that either increase thresholds for visceral perception or modify sensations is currently under investigation.
This includes agents of several groups, such as octreotide, loxiglumide, ondansetron and other serotonin blockers, fedotozine and tricyclic antidepressant at low doses.
New drugs for the treatment of functional dyspepsia
Conclusions – Although these new drugs may improve the pharmacological approach to the treatment of functional dyspepsia, there is a need for randomized, controlled trials to assess their efficacy. Moreover, difficulties related to the identification of the mechanisms underlying symptoms may limit the utilization of these new drugs.
Intestinal diseases, drug therapy.
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Dispepsia: Causas, Síntomas y Tratamiento
Psychotropic medications for the treatment of functional gastrointestinal disorders. Clin Perspect Gastroenterol ;2: Effect of the kappa agonist fedotozine on perception of gastric distension in healthy humans. Aliment Pharmacol Ther ; Influence of buspirone-induced fundus relaxation on the perception of gastric distension in man [abstract].
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Ondansetron reduces nausea induced by gastroduodenal stimulation without changing gastric motility. Am J Physiol ; Management of nonulcer dyspepsia. N Engl J Med ; Double-blind dose-response multicenter comparison of fedotozine and placebo in treatment of nonulcer dyspepsia. Role of cholecystokinin in the regulation of gastric emptying and pancreatic enzyme secretion in humans.
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Abnormal perception of visceral pain in response to gastric dlspepsia in chronic idiopathic dyspepsia.
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Gastrointestinal motor effects of erythromycin. Motility-modifying agents and management of disorders of gastrointestinal motility. Gastroenterology ; Suppl 1: Amitryptiline improves the quality of life in patients with nonulcer dyspepsia [abstract ].
Dolor estomacal no ulceroso – Síntomas y causas – Mayo Clinic
Efficacy and safety of the peripheral kappa agonist fedotozine versus placebo in the treatment of functional dyspepsia. Dyspepsia, antral motor dysfunction, and gastric stasis of solids.
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Drug treatment of functional dyspepsia. Am J Gastroenterol ; All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Services on Demand Journal. How to cite this article.